The A487 between Llanon and Aberarth is currently closed following a collision on the coast road.
Motorists are being urged to avoid the area and to find alternative routes for travel as the main road between Aberystwyth and Aberaeron is closed.
In a post to social media, Dyfed-Powys Police said: "A487 - Aberarth to Llanon "The road is currently closed due to a collision "Please avoid the area and find alternative routes for your journey."